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Gene Information
Gene Name
DHODH
Organism
Homo sapiens (Human)
Gene Length
395
Protein Names
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)
Target Name
dihydroorotate dehydrogenase
Target Type
Successful target
Gene Age
1292 ( ENSG00000102967 )
Evolutionary Stage
Cellular_organisms
AlphaFoldDB
Q02127
Gene Card
DHODH
Uniprot ID
Q02127
Pfam
PF01180
In ASD
no
Allosteric Prediction
yes (0.378953281)
Ortholog in Animals
Alpaca_ DHODH ( ortholog_one2one )
GuineaPig_ DHODH ( ortholog_one2one )
Macaque_ DHODH ( ortholog_one2one )
Mouse_ Dhodh ( ortholog_one2one )
Pig_ DHODH ( ortholog_one2one )
Rat_ Dhodh ( ortholog_one2one )
Rabbit_ DHODH ( ortholog_one2one )
Ohnologs
NA
Paralogs
FDXR, DPYD
Tissue
liver
Tissue Specificity
NA
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1D3G
(X-ray
1.60A
)
1D3H
(X-ray
1.80A
)
2B0M
(X-ray
2.00A
)
2BXV
(X-ray
2.15A
)
2FPT
(X-ray
2.40A
)
2FPV
(X-ray
1.80A
)
2FPY
(X-ray
2.00A
)
2FQI
(X-ray
1.95A
)
2PRH
(X-ray
2.40A
)
2PRL
(X-ray
2.10A
)
2PRM
(X-ray
3.00A
)
2WV8
(X-ray
1.90A
)
3F1Q
(X-ray
2.00A
)
3FJ6
(X-ray
1.80A
)
3FJL
(X-ray
1.90A
)
3G0U
(X-ray
2.00A
)
3G0X
(X-ray
1.80A
)
3KVJ
(X-ray
1.94A
)
3KVK
(X-ray
2.05A
)
3KVL
(X-ray
1.85A
)
3KVM
(X-ray
2.00A
)
3U2O
(X-ray
2.18A
)
3W7R
(X-ray
1.68A
)
3ZWS
(X-ray
1.60A
)
3ZWT
(X-ray
1.55A
)
4IGH
(X-ray
1.30A
)
4JGD
(X-ray
2.05A
)
4JS3
(X-ray
2.00A
)
4JTS
(X-ray
2.21A
)
4JTT
(X-ray
2.10A
)
4JTU
(X-ray
1.90A
)
4LS0
(X-ray
2.07A
)
4LS1
(X-ray
2.20A
)
4LS2
(X-ray
2.27A
)
4OQV
(X-ray
1.23A
)
4RK8
(X-ray
2.22A
)
4RKA
(X-ray
2.71A
)
4RLI
(X-ray
2.50A
)
4RR4
(X-ray
2.38A
)
4YLW
(X-ray
1.79A
)
4ZL1
(X-ray
1.86A
)
4ZMG
(X-ray
1.90A
)
5H2Z
(X-ray
1.58A
)
5H73
(X-ray
1.58A
)
5HIN
(X-ray
1.60A
)
5HQE
(X-ray
1.62A
)
5K9C
(X-ray
1.66A
)
5K9D
(X-ray
1.70A
)
5MUT
(X-ray
1.75A
)
5MVC
(X-ray
1.85A
)
5MVD
(X-ray
1.95A
)
5TCE
(NMR
-
)
5ZF4
(X-ray
1.66A
)
5ZF7
(X-ray
1.79A
)
5ZF8
(X-ray
1.70A
)
5ZF9
(X-ray
1.77A
)
5ZFA
(X-ray
1.75A
)
5ZFB
(X-ray
2.00A
)
6CJF
(X-ray
1.63A
)
6CJG
(X-ray
2.85A
)
6ET4
(X-ray
1.70A
)
6FMD
(X-ray
1.58A
)
6GK0
(X-ray
1.85A
)
6IDJ
(X-ray
1.90A
)
6J3B
(X-ray
1.60A
)
6J3C
(X-ray
1.85A
)
6JMD
(X-ray
1.78A
)
6JME
(X-ray
1.80A
)
6LP6
(X-ray
1.79A
)
6LP7
(X-ray
1.80A
)
6LP8
(X-ray
1.79A
)
6LZL
(X-ray
1.98A
)
6M2B
(X-ray
1.76A
)
6OC0
(X-ray
1.40A
)
6OC1
(X-ray
2.70A
)
6QU7
(X-ray
1.52A
)
6SYP
(X-ray
1.80A
)
6VND
(X-ray
1.97A
)
7K2U
(X-ray
1.73A
)
8DHF
(X-ray
1.78A
)
8DHG
(X-ray
1.85A
)
8DHH
(X-ray
2.02A
)
DBSNP
rs3213422
rs267606765
rs201230446
rs267606766
rs267606769
rs267606767
rs267606767
rs267606768
rs201947120
rs779076692
Subcellular location [CC]
Mitochondrion inner membrane {ECO:0000269|PubMed:10727948};
Single-pass membrane protein {ECO:0000269|PubMed:10727948}.
Mouse PG classification
NA
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