| Gene Information | |
|---|---|
| Gene Name | DHODH |
| Organism | Homo sapiens (Human) |
| Gene Length | 395 |
| Protein Names | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) |
| Target Name | dihydroorotate dehydrogenase (quinone), mitochondrial |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000102967 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q02127 |
| Gene Card | DHODH |
| Uniprot ID | Q02127 |
| Pfam | PF01180 |
| In ASD | no |
| Allosteric Prediction | yes (0.378953281) |
| Ortholog in Animals | Alpaca_ DHODH ( ortholog_one2one ) GuineaPig_ DHODH ( ortholog_one2one ) Macaque_ DHODH ( ortholog_one2one ) Mouse_ Dhodh ( ortholog_one2one ) Pig_ DHODH ( ortholog_one2one ) Rat_ Dhodh ( ortholog_one2one ) Rabbit_ DHODH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FDXR, DPYD |
| Tissue | liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D3G (X-ray 1.60A ) 1D3H (X-ray 1.80A ) 2B0M (X-ray 2.00A ) 2BXV (X-ray 2.15A ) 2FPT (X-ray 2.40A ) 2FPV (X-ray 1.80A ) 2FPY (X-ray 2.00A ) 2FQI (X-ray 1.95A ) 2PRH (X-ray 2.40A ) 2PRL (X-ray 2.10A ) 2PRM (X-ray 3.00A ) 2WV8 (X-ray 1.90A ) 3F1Q (X-ray 2.00A ) 3FJ6 (X-ray 1.80A ) 3FJL (X-ray 1.90A ) 3G0U (X-ray 2.00A ) 3G0X (X-ray 1.80A ) 3KVJ (X-ray 1.94A ) 3KVK (X-ray 2.05A ) 3KVL (X-ray 1.85A ) 3KVM (X-ray 2.00A ) 3U2O (X-ray 2.18A ) 3W7R (X-ray 1.68A ) 3ZWS (X-ray 1.60A ) 3ZWT (X-ray 1.55A ) 4IGH (X-ray 1.30A ) 4JGD (X-ray 2.05A ) 4JS3 (X-ray 2.00A ) 4JTS (X-ray 2.21A ) 4JTT (X-ray 2.10A ) 4JTU (X-ray 1.90A ) 4LS0 (X-ray 2.07A ) 4LS1 (X-ray 2.20A ) 4LS2 (X-ray 2.27A ) 4OQV (X-ray 1.23A ) 4RK8 (X-ray 2.22A ) 4RKA (X-ray 2.71A ) 4RLI (X-ray 2.50A ) 4RR4 (X-ray 2.38A ) 4YLW (X-ray 1.79A ) 4ZL1 (X-ray 1.86A ) 4ZMG (X-ray 1.90A ) 5H2Z (X-ray 1.58A ) 5H73 (X-ray 1.58A ) 5HIN (X-ray 1.60A ) 5HQE (X-ray 1.62A ) 5K9C (X-ray 1.66A ) 5K9D (X-ray 1.70A ) 5MUT (X-ray 1.75A ) 5MVC (X-ray 1.85A ) 5MVD (X-ray 1.95A ) 5TCE (NMR - ) 5ZF4 (X-ray 1.66A ) 5ZF7 (X-ray 1.79A ) 5ZF8 (X-ray 1.70A ) 5ZF9 (X-ray 1.77A ) 5ZFA (X-ray 1.75A ) 5ZFB (X-ray 2.00A ) 6CJF (X-ray 1.63A ) 6CJG (X-ray 2.85A ) 6ET4 (X-ray 1.70A ) 6FMD (X-ray 1.58A ) 6GK0 (X-ray 1.85A ) 6IDJ (X-ray 1.90A ) 6J3B (X-ray 1.60A ) 6J3C (X-ray 1.85A ) 6JMD (X-ray 1.78A ) 6JME (X-ray 1.80A ) 6LP6 (X-ray 1.79A ) 6LP7 (X-ray 1.80A ) 6LP8 (X-ray 1.79A ) 6LZL (X-ray 1.98A ) 6M2B (X-ray 1.76A ) 6OC0 (X-ray 1.40A ) 6OC1 (X-ray 2.70A ) 6QU7 (X-ray 1.52A ) 6SYP (X-ray 1.80A ) 6VND (X-ray 1.97A ) 7K2U (X-ray 1.73A ) 8DHF (X-ray 1.78A ) 8DHG (X-ray 1.85A ) 8DHH (X-ray 2.02A ) |
| DBSNP | rs3213422 rs267606765 rs201230446 rs267606766 rs267606769 rs267606767 rs267606767 rs267606768 rs201947120 rs779076692 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:10727948}; Single-pass membrane protein {ECO:0000269|PubMed:10727948}. |
| Mouse PG classification | NA |
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