| Gene Information | |
|---|---|
| Gene Name | DHFR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 187 |
| Protein Names | Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000178700 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q86XF0 |
| Gene Card | DHFR2 |
| Uniprot ID | Q86XF0 |
| Pfam | PF00186 |
| In ASD | no |
| Allosteric Prediction | no (-0.591171571) |
| Ortholog in Animals | Alpaca_ DHFR2 ( ortholog_one2one ) Macaque_ DHFR2 ( ortholog_one2one ) Mouse_ Dhfr ( ortholog_one2many ) Rat_ Dhfr ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | TYMS, DHFR |
| Tissue | NA |
| Tissue Specificity | Expressed in numerous cell lines. {ECO:0000269|PubMed:21876184}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17855824 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:21876184, ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}. |
| Mouse PG classification | NA |
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