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Gene Information
Gene Name
DHFR
Organism
Homo sapiens (Human)
Gene Length
187
Protein Names
Dihydrofolate reductase (EC 1.5.1.3)
Target Name
dihydrofolate reductase
Target Type
Successful target
Gene Age
1292 ( ENSG00000228716 )
Evolutionary Stage
Euk+Bac
AlphaFoldDB
P00374
Gene Card
DHFR
Uniprot ID
P00374
Pfam
PF00186
In ASD
yes
Allosteric Prediction
yes (0.965674087)
Ortholog in Animals
Alpaca_ DHFR ( ortholog_one2one )
Mouse_ Dhfr ( ortholog_one2many )
Rat_ Dhfr ( ortholog_one2many )
Ohnologs
NA
Paralogs
TYMS, DHFR2
Tissue
NA
Tissue Specificity
Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1BOZ
(X-ray
2.10A
)
1DHF
(X-ray
2.30A
)
1DLR
(X-ray
2.30A
)
1DLS
(X-ray
2.30A
)
1DRF
(X-ray
2.00A
)
1HFP
(X-ray
2.10A
)
1HFQ
(X-ray
2.10A
)
1HFR
(X-ray
2.10A
)
1KMS
(X-ray
1.09A
)
1KMV
(X-ray
1.05A
)
1MVS
(X-ray
1.90A
)
1MVT
(X-ray
1.80A
)
1OHJ
(X-ray
2.50A
)
1OHK
(X-ray
2.50A
)
1PD8
(X-ray
2.10A
)
1PD9
(X-ray
2.20A
)
1PDB
(X-ray
2.20A
)
1S3U
(X-ray
2.50A
)
1S3V
(X-ray
1.80A
)
1S3W
(X-ray
1.90A
)
1U71
(X-ray
2.20A
)
1U72
(X-ray
1.90A
)
1YHO
(NMR
-
)
2C2S
(X-ray
1.40A
)
2C2T
(X-ray
1.50A
)
2DHF
(X-ray
2.30A
)
2W3A
(X-ray
1.50A
)
2W3B
(X-ray
1.27A
)
2W3M
(X-ray
1.60A
)
3EIG
(X-ray
1.70A
)
3F8Y
(X-ray
1.45A
)
3F8Z
(X-ray
2.01A
)
3F91
(X-ray
1.90A
)
3FS6
(X-ray
1.23A
)
3GHC
(X-ray
1.30A
)
3GHV
(X-ray
1.30A
)
3GHW
(X-ray
1.24A
)
3GI2
(X-ray
1.53A
)
3GYF
(X-ray
1.70A
)
3L3R
(X-ray
2.00A
)
3N0H
(X-ray
1.92A
)
3NTZ
(X-ray
1.35A
)
3NU0
(X-ray
1.35A
)
3NXO
(X-ray
1.35A
)
3NXR
(X-ray
1.35A
)
3NXT
(X-ray
1.70A
)
3NXV
(X-ray
1.90A
)
3NXX
(X-ray
1.35A
)
3NXY
(X-ray
1.90A
)
3NZD
(X-ray
1.80A
)
3OAF
(X-ray
1.70A
)
3S3V
(X-ray
1.53A
)
3S7A
(X-ray
1.80A
)
4DDR
(X-ray
2.05A
)
4G95
(X-ray
1.35A
)
4KAK
(X-ray
1.80A
)
4KBN
(X-ray
1.84A
)
4KD7
(X-ray
2.72A
)
4KEB
(X-ray
1.45A
)
4KFJ
(X-ray
1.76A
)
4M6J
(X-ray
1.20A
)
4M6K
(X-ray
1.40A
)
4M6L
(X-ray
1.70A
)
4QHV
(X-ray
1.61A
)
4QJC
(X-ray
1.62A
)
5HPB
(X-ray
1.65A
)
5HQY
(X-ray
1.46A
)
5HQZ
(X-ray
1.46A
)
5HSR
(X-ray
1.21A
)
5HSU
(X-ray
1.46A
)
5HT4
(X-ray
1.60A
)
5HT5
(X-ray
1.90A
)
5HUI
(X-ray
1.46A
)
5HVB
(X-ray
1.60A
)
5HVE
(X-ray
1.46A
)
5SD6
(X-ray
2.15A
)
5SD7
(X-ray
1.80A
)
5SD8
(X-ray
2.05A
)
5SD9
(X-ray
2.10A
)
5SDA
(X-ray
2.45A
)
5SDB
(X-ray
1.55A
)
6A7C
(X-ray
2.06A
)
6A7E
(X-ray
1.85A
)
6DAV
(X-ray
1.55A
)
6DE4
(X-ray
2.41A
)
6VCJ
(X-ray
2.34A
)
7ESE
(X-ray
1.85A
)
7XI7
(X-ray
1.65A
)
DBSNP
rs387906619
rs121913223
Subcellular location [CC]
Mitochondrion {ECO:0000250|UniProtKB:P00375}. Cytoplasm {ECO:0000250|UniProtKB:P00375}.
Mouse PG classification
NA
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