| Gene Information | |
|---|---|
| Gene Name | DGKZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 928 |
| Protein Names | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) |
| Target Name | diacylglycerol kinase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000149091 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13574 |
| Gene Card | DGKZ |
| Uniprot ID | Q13574 |
| Pfam | PF12796; PF00130; PF00609; PF00781 |
| In ASD | no |
| Allosteric Prediction | yes (0.08128175) |
| Ortholog in Animals | Alpaca_ DGKZ ( ortholog_one2one ) Dog_ DGKZ ( ortholog_one2one ) GuineaPig_ DGKZ ( ortholog_one2one ) Macaque_ DGKZ ( ortholog_one2one ) Mouse_ Dgkz ( ortholog_one2one ) Pig_ DGKZ ( ortholog_one2one ) Rat_ Dgkz ( ortholog_one2one ) |
| Ohnologs | DGKI |
| Paralogs | DGKQ, DGKE, DGKG, DGKH, DGKI, DGKB, DGKD, DGKA, DGKK |
| Tissue | NA |
| Tissue Specificity | Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. {ECO:0000269|PubMed:8626588}.; [Isoform 2]: Predominantly expressed in muscle. {ECO:0000269|PubMed:9159104}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5ELQ (X-ray 1.10A ) |
| DBSNP | rs17854149 rs1317826 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11257115, ECO:0000269|PubMed:15157668, ECO:0000269|PubMed:9159104, ECO:0000269|PubMed:9716136}. Cytoplasm, cytosol {ECO:0000269|PubMed:11257115, ECO:0000269|PubMed:22627129}. Cell membrane {ECO:0000269|PubMed:11257115}. Cell projection, lamellipodium {ECO:0000269|PubMed:15157668}. |
| Mouse PG classification | NA |
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