| Gene Information | |
|---|---|
| Gene Name | DGKQ |
| Organism | Homo sapiens (Human) |
| Gene Length | 942 |
| Protein Names | Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) |
| Target Name | diacylglycerol kinase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000145214 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52824 |
| Gene Card | DGKQ |
| Uniprot ID | P52824 |
| Pfam | PF00130; PF00609; PF00781; PF00788 |
| In ASD | yes |
| Allosteric Prediction | no (-0.361381251) |
| Ortholog in Animals | Alpaca_ DGKQ ( ortholog_one2one ) Dog_ DGKQ ( ortholog_one2one ) GuineaPig_ DGKQ ( ortholog_one2one ) Macaque_ DGKQ ( ortholog_one2one ) Mouse_ Dgkq ( ortholog_one2one ) Pig_ DGKQ ( ortholog_one2one ) Rat_ Dgkq ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DGKE, DGKG, DGKH, DGKI, DGKB, DGKD, DGKA, DGKK, DGKZ |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17855876 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15632189}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P5E8}. Cell membrane {ECO:0000269|PubMed:10066731, ECO:0000269|PubMed:15632189}. Synapse {ECO:0000250|UniProtKB:Q6P5E8}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10066731}. Nucleus {ECO:0000269|PubMed:12799190}. Nucleus speckle {ECO:0000269|PubMed:12799190}. Nucleus matrix {ECO:0000250|UniProtKB:D3ZEY4}. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). Translocates to the nucleus in response to thrombin stimulation (Probable). Association with the nuclear matrix is regulated by nerve growth factor (By similarity). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:15632189, ECO:0000305|PubMed:11309392}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |