| Gene Information | |
|---|---|
| Gene Name | DGKE |
| Organism | Homo sapiens (Human) |
| Gene Length | 567 |
| Protein Names | Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) |
| Target Name | diacylglycerol kinase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000153933 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52429 |
| Gene Card | DGKE |
| Uniprot ID | P52429 |
| Pfam | PF00130; PF00609; PF00781 |
| In ASD | no |
| Allosteric Prediction | no (-0.32633365) |
| Ortholog in Animals | Alpaca_ DGKE ( ortholog_one2one ) Dog_ DGKE ( ortholog_one2one ) GuineaPig_ DGKE ( ortholog_one2one ) Macaque_ DGKE ( ortholog_one2one ) Mouse_ Dgke ( ortholog_one2one ) Pig_ DGKE ( ortholog_one2one ) Rat_ Dgke ( ortholog_one2one ) Rabbit_ DGKE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DGKQ, DGKG, DGKH, DGKI, DGKB, DGKD, DGKA, DGKK, DGKZ |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level). {ECO:0000269|PubMed:23542698}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs312262694 rs312262695 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:23542698}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:23542698}. |
| Mouse PG classification | NA |
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