| Gene Information | |
|---|---|
| Gene Name | DGKD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1214 |
| Protein Names | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) |
| Target Name | diacylglycerol kinase delta |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000077044 ) 3 ( ENSG00000280873 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16760 |
| Gene Card | DGKD |
| Uniprot ID | Q16760 |
| Pfam | PF00130; PF00609; PF00781; PF00169; PF07647 |
| In ASD | no |
| Allosteric Prediction | yes (0.247937812) |
| Ortholog in Animals | Alpaca_ DGKD ( ortholog_one2one ) Dog_ DGKD ( ortholog_one2one ) GuineaPig_ DGKD ( ortholog_one2one ) Macaque_ DGKD ( ortholog_one2one ) Mouse_ Dgkd ( ortholog_one2one ) Pig_ DGKD ( ortholog_one2one ) Rat_ Dgkd ( ortholog_one2one ) Rabbit_ DGKD ( ortholog_one2one ) |
| Ohnologs | DGKH |
| Paralogs | DGKQ, DGKE, DGKG, DGKH, DGKI, DGKB, DGKA, DGKK, DGKZ |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: Widely expressed. {ECO:0000269|PubMed:12200442}.; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen. {ECO:0000269|PubMed:12200442}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1R79 (NMR - ) 3BQ7 (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane, clathrin-coated pit {ECO:0000269|PubMed:17880279}. Cytoplasm {ECO:0000269|PubMed:12200442}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12200442}; Peripheral membrane protein {ECO:0000269|PubMed:12200442}. Cytoplasm {ECO:0000269|PubMed:12200442}. Note=Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters (PubMed:12200442). Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane (PubMed:12084710). {ECO:0000269|PubMed:12084710, ECO:0000269|PubMed:12200442}. |
| Mouse PG classification | NA |
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