| Gene Information | |
|---|---|
| Gene Name | CEP55 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000138180 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q53EZ4 |
| Gene Card | CEP55 |
| Uniprot ID | Q53EZ4 |
| Pfam | PF12180 |
| In ASD | no |
| Allosteric Prediction | no (-0.348087469) |
| Ortholog in Animals | Alpaca_ CEP55 ( ortholog_one2one ) Dog_ CEP55 ( ortholog_one2one ) GuineaPig_ CEP55 ( ortholog_one2one ) Macaque_ CEP55 ( ortholog_one2one ) Mouse_ Cep55 ( ortholog_one2one ) Pig_ CEP55 ( ortholog_one2one ) Rat_ Cep55 ( ortholog_one2one ) Rabbit_ CEP55 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, bone.marrow, dura.mater, testis, tongue, brain, spleen |
| Tissue Specificity | Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:16406728, ECO:0000269|PubMed:28264986, ECO:0000269|PubMed:28295209}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3E1R (X-ray 2.00A ) 3WUT (X-ray 2.30A ) 3WUU (X-ray 2.90A ) 3WUV (X-ray 2.79A ) |
| DBSNP | rs3740370 rs7080916 rs7072484 rs2293277 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:28264986}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16198290}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16198290}. Cleavage furrow {ECO:0000269|PubMed:16198290}. Midbody, Midbody ring {ECO:0000269|PubMed:16198290, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:28264986}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000269|PubMed:16198290}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |