| Gene Information | |
|---|---|
| Gene Name | DGAT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 388 |
| Protein Names | Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) |
| Target Name | diacylglycerol o-acyltransferase 2 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000062282 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96PD7 |
| Gene Card | DGAT2 |
| Uniprot ID | Q96PD7 |
| Pfam | PF03982 |
| In ASD | no |
| Allosteric Prediction | no (-0.142079996) |
| Ortholog in Animals | Alpaca_ DGAT2 ( ortholog_one2one ) Dog_ DGAT2 ( ortholog_one2one ) GuineaPig_ DGAT2 ( ortholog_one2one ) Macaque_ DGAT2 ( ortholog_one2one ) Mouse_ Dgat2 ( ortholog_one2one ) Rat_ Dgat2 ( ortholog_one2one ) |
| Ohnologs | AWAT2, DGAT2L6, AWAT1, MOGAT1 |
| Paralogs | AWAT2, AWAT1, DGAT2L6, MOGAT3, MOGAT2, MOGAT1 |
| Tissue | adipose.tissue, zone.of.skin |
| Tissue Specificity | Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. {ECO:0000269|PubMed:11481335, ECO:0000269|PubMed:14521909}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs869025595 rs34421064 rs34113941 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14521909, ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000269|PubMed:14521909}. Lipid droplet {ECO:0000269|PubMed:27184406}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}. |
| Mouse PG classification | NA |
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