| Gene Information | |
|---|---|
| Gene Name | DERL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 239 |
| Protein Names | Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000072849 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9GZP9 |
| Gene Card | DERL2 |
| Uniprot ID | Q9GZP9 |
| Pfam | PF04511 |
| In ASD | no |
| Allosteric Prediction | no (-0.756444953) |
| Ortholog in Animals | Alpaca_ DERL2 ( ortholog_one2one ) Dog_ DERL2 ( ortholog_one2one ) GuineaPig_ DERL2 ( ortholog_one2one ) Macaque_ DERL2 ( ortholog_one2one ) Mouse_ Derl2 ( ortholog_one2one ) Pig_ DERL2 ( ortholog_one2one ) Rat_ Derl2 ( ortholog_one2one ) Rabbit_ DERL2 ( ortholog_one2one ) |
| Ohnologs | DERL3 |
| Paralogs | DERL3, DERL1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.092313(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}. |
| Mouse PG classification | NA |
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