| Gene Information | |
|---|---|
| Gene Name | DER4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 556 |
| Protein Names | Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q01638 |
| Gene Card | IL1RL1 |
| Uniprot ID | Q01638 |
| Pfam | PF07679; PF01582 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver. {ECO:0000269|PubMed:11478810, ECO:0000269|PubMed:19508382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KC3 (X-ray 3.27A ) |
| DBSNP | rs1041973 rs4988956 rs10192036 rs10204137 rs10192157 rs10206753 |
| Subcellular location [CC] | [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane {ECO:0000269|PubMed:11478810}; Single-pass type I membrane protein {ECO:0000269|PubMed:11478810}. |
| Mouse PG classification | NA |
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