| Gene Information | |
|---|---|
| Gene Name | DENND2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1137 |
| Protein Names | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166444 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P78524 |
| Gene Card | DENND2B |
| Uniprot ID | P78524 |
| Pfam | PF03455; PF02141; PF03456 |
| In ASD | no |
| Allosteric Prediction | no (-0.716749611) |
| Ortholog in Animals | Alpaca_ DENND2B ( ortholog_one2one ) Dog_ DENND2B ( ortholog_one2one ) GuineaPig_ DENND2B ( ortholog_one2one ) Macaque_ DENND2B ( ortholog_one2one ) Mouse_ Denn2b ( ortholog_one2one ) Pig_ DENND2B ( ortholog_one2one ) Rat_ Dennd2b ( ortholog_one2one ) Rabbit_ DENND2B ( ortholog_one2one ) |
| Ohnologs | DENND2A, DENND2D, DENND2C |
| Paralogs | DENND2C, DENND2A, DENND2D |
| Tissue | NA |
| Tissue Specificity | Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level). {ECO:0000269|PubMed:10229203}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3794153 rs3812762 rs17853683 rs11042047 rs17853682 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cell cortex {ECO:0000269|PubMed:29030480}. Cell membrane {ECO:0000269|PubMed:29030480}. Recycling endosome {ECO:0000269|PubMed:29030480}. Note=Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton. {ECO:0000269|PubMed:29030480}. |
| Mouse PG classification | NA |
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