| Gene Information | |
|---|---|
| Gene Name | DELE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 515 |
| Protein Names | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000081791 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14154 |
| Gene Card | DELE1 |
| Uniprot ID | Q14154 |
| Pfam | PF08238 |
| In ASD | no |
| Allosteric Prediction | no (-1.075554697) |
| Ortholog in Animals | Alpaca_ DELE1 ( ortholog_one2one ) Dog_ DELE1 ( ortholog_one2one ) GuineaPig_ DELE1 ( ortholog_one2one ) Macaque_ DELE1 ( ortholog_one2one ) Mouse_ Dele1 ( ortholog_one2one ) Pig_ DELE1 ( ortholog_one2one ) Rat_ Dele1 ( ortholog_one2one ) Rabbit_ DELE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SEL1L2, SEL1L3, SEL1L, LRP2BP |
| Tissue | NA |
| Tissue Specificity | Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon. {ECO:0000269|PubMed:8590280}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34438707 rs17850821 rs10036567 rs351260 rs10056676 |
| Subcellular location [CC] | [DAP3-binding cell death enhancer 1]: Mitochondrion {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}. Mitochondrion inner membrane {ECO:0000269|PubMed:32132707}. Note=Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1). {ECO:0000269|PubMed:32132707}.; [DAP3-binding cell death enhancer 1 short form]: Cytoplasm, cytosol {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}. Note=This short form is generated by proteolytic processing by OMA1 in response to mitochondrial stress, leading to translocation to the cytosol. {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |