Gene Information
Gene NameDEGS2
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesSphingolipid delta(4)-desaturase/C4-monooxygenase DES2 (EC 1.14.18.5) (EC 1.14.19.17) (Degenerative spermatocyte homolog 2) (Sphingolipid 4-desaturase) (Sphingolipid C4-monooxygenase)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000168350 )
Evolutionary StageEukaryota
AlphaFoldDBQ6QHC5
Gene CardDEGS2
Uniprot IDQ6QHC5
PfamPF00487; PF08557
In ASDno
Allosteric Predictionno (-0.492460606)
Ortholog in AnimalsAlpaca_ DEGS2 ( ortholog_one2one )
Dog_ DEGS2 ( ortholog_one2one )
GuineaPig_ DEGS2 ( ortholog_one2one )
Macaque_ DEGS2 ( ortholog_one2one )
Mouse_ Degs2 ( ortholog_one2one )
Pig_ DEGS2 ( ortholog_one2one )
Rat_ Degs2 ( ortholog_one2one )
OhnologsDEGS1
ParalogsDEGS1
TissueNA
Tissue SpecificityHighly expressed in skin, intestine and kidney. {ECO:0000269|PubMed:15063729}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs7157599  rs4905937 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R2F2};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2}.
Mouse PG classificationNA
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