| Gene Information | |
|---|---|
| Gene Name | FOLR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 257 |
| Protein Names | Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18) |
| Target Name | folate receptor alpha |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000110195 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P15328 |
| Gene Card | FOLR1 |
| Uniprot ID | P15328 |
| Pfam | PF03024 |
| In ASD | no |
| Allosteric Prediction | yes (0.436012671) |
| Ortholog in Animals | Alpaca_ FOLR1 ( ortholog_one2one ) Dog_ FOLR1 ( ortholog_one2one ) GuineaPig_ FOLR1 ( ortholog_one2one ) Macaque_ FOLR1 ( ortholog_one2one ) Mouse_ Folr1 ( ortholog_one2one ) Pig_ FOLR1 ( ortholog_one2one ) Rat_ Folr1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FOLR3, FOLR2, IZUMO1R, RTBDN |
| Tissue | kidney, lung, oviduct, salivary.gland, cortex.of.kidney, minor.salivary.gland |
| Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4KM6 (X-ray 1.55A ) 4KM7 (X-ray 1.80A ) 4KMX (X-ray 2.20A ) 4LRH (X-ray 2.80A ) 5IZQ (X-ray 3.60A ) |
| DBSNP | rs7928649 rs1801932 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}. |
| Mouse PG classification | NA |
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