| Gene Information | |
|---|---|
| Gene Name | DEF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 94 |
| Protein Names | Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q01523 |
| Gene Card | DEFA5 |
| Uniprot ID | Q01523 |
| Pfam | PF00323; PF00879 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the gastrointestinal, reproductive, and urinary tracts (at protein level) (PubMed:1429669, PubMed:12021776, PubMed:9588893, PubMed:22359618). Expressed in Paneth cells of the small intestine (at protein level) (PubMed:1429669, PubMed:12021776). Expressed throughout the urothelium of the lower urinary tract and in the collecting tubules of the kidney (at protein level) (PubMed:22359618). Expressed in stratified squamous epithelial cells of the female genital tract epithelia, such as in vagina, ectocervix, endocervix, endometrium, and fallopian tube (at protein level) (PubMed:9588893). Endometrial expression correlates with stages of the menstrual cycle: Expression is low during the early proliferative phase, increased during the mid- to late proliferative phase, peaks during the early secretory phase of the cycle, and decreases during the mid- to late secretory phase (PubMed:9588893). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:1429669, ECO:0000269|PubMed:22359618, ECO:0000269|PubMed:9588893}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ZMP (X-ray 1.65A ) 2LXZ (NMR - ) 2MIT (NMR - ) 3I5W (X-ray 1.63A ) 4E82 (X-ray 1.70A ) 4E83 (X-ray 1.90A ) 4E86 (X-ray 2.75A ) 4RBW (X-ray 1.50A ) 4RBX (X-ray 1.10A ) 5CUI (X-ray 2.40A ) 5CUJ (X-ray 2.08A ) 5CUM (X-ray 1.75A ) |
| DBSNP | rs7839771 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Note=Stored as propeptide HD5(20-94) in secretory granules of small intestinal Paneth cells and found in the ileum lumen as processed mature peptides, predominantly in the HD5(63-94) form (PubMed:12021776). Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form (PubMed:12021776). Secreted into the female genital tract lumen (PubMed:9588893). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. |
| Mouse PG classification | NA |
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