| Gene Information | |
|---|---|
| Gene Name | UNQ732/PRO1418 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Sperm equatorial segment protein 1 (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6UW49 |
| Gene Card | SPESP1 |
| Uniprot ID | Q6UW49 |
| Pfam | PF15754 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung. {ECO:0000269|PubMed:12773409}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3743091 rs16952684 rs3743093 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12773409}. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity). {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409}. |
| Mouse PG classification | NA |
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