| Gene Information | |
|---|---|
| Gene Name | DDX5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 614 |
| Protein Names | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68) |
| Target Name | atp-dependent rna helicase ddx5 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000108654 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P17844 |
| Gene Card | DDX5 |
| Uniprot ID | P17844 |
| Pfam | PF00270; PF00271; PF08061 |
| In ASD | no |
| Allosteric Prediction | yes (0.51579305) |
| Ortholog in Animals | Alpaca_ DDX5 ( ortholog_one2one ) Dog_ DDX5 ( ortholog_one2one ) GuineaPig_ DDX5 ( ortholog_one2one ) Macaque_ DDX5 ( ortholog_one2one ) Mouse_ Ddx5 ( ortholog_one2one ) Pig_ DDX5 ( ortholog_one2one ) Rat_ Ddx5 ( ortholog_one2one ) Rabbit_ DDX5 ( ortholog_one2one ) |
| Ohnologs | DDX17 |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FE2 (X-ray 2.60A ) 4A4D (X-ray 2.70A ) |
| DBSNP | rs1140409 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22034099}. Nucleus, nucleolus {ECO:0000269|PubMed:10837141, ECO:0000269|PubMed:1996094}. Nucleus speckle {ECO:0000269|PubMed:24644279}. Cytoplasm {ECO:0000269|PubMed:22034099}. Note=During the G0 phase, predominantly located in the nucleus. Cytoplasmic levels increase during the G1/S phase. During the M phase, located at the vicinity of the condensed chromosomes. At G1, localizes in the cytoplasm. {ECO:0000269|PubMed:22034099}. |
| Mouse PG classification | NA |
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