| Gene Information | |
|---|---|
| Gene Name | DDX42 |
| Organism | Homo sapiens (Human) |
| Gene Length | 938 |
| Protein Names | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000198231 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86XP3 |
| Gene Card | DDX42 |
| Uniprot ID | Q86XP3 |
| Pfam | PF00270; PF00271 |
| In ASD | no |
| Allosteric Prediction | no (-0.335153622) |
| Ortholog in Animals | Alpaca_ DDX42 ( ortholog_one2one ) Dog_ DDX42 ( ortholog_one2one ) GuineaPig_ DDX42 ( ortholog_one2one ) Macaque_ DDX42 ( ortholog_one2one ) Mouse_ Ddx42 ( ortholog_one2one ) Pig_ DDX42 ( ortholog_one2one ) Rat_ Ddx42 ( ortholog_one2one ) Rabbit_ DDX42 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX28, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | NA |
| Tissue Specificity | Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. {ECO:0000269|PubMed:10727850, ECO:0000269|PubMed:16397294}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7EVN (EM 2.60A ) 8DPE (X-ray 1.53A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19377511}. Nucleus {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.; [Isoform 2]: Nucleus, Cajal body {ECO:0000269|PubMed:12234937}. Nucleus speckle {ECO:0000269|PubMed:12234937}. |
| Mouse PG classification | NA |
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