| Gene Information | |
|---|---|
| Gene Name | DGAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 488 |
| Protein Names | Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) |
| Target Name | diacylglycerol acyltransferase 1 |
| Target Type | Successful target |
| Gene Age | 1064 ( ENSG00000185000 ) 3 ( ENSG00000285482 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75907 |
| Gene Card | DGAT1 |
| Uniprot ID | O75907 |
| Pfam | PF03062 |
| In ASD | no |
| Allosteric Prediction | yes (0.283232987) |
| Ortholog in Animals | Alpaca_ DGAT1 ( ortholog_one2one ) Dog_ DGAT1 ( ortholog_one2one ) GuineaPig_ DGAT1 ( ortholog_one2one ) Macaque_ DGAT1 ( ortholog_one2one ) Mouse_ Dgat1 ( ortholog_one2one ) Pig_ DGAT1 ( ortholog_one2one ) Rat_ Dgat1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SOAT2, SOAT1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6VP0 (EM 3.10A ) 6VYI (EM 3.00A ) 6VZ1 (EM 3.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2A7}; Multi-pass membrane protein {ECO:0000269|PubMed:32433610, ECO:0000269|PubMed:32433611}. |
| Mouse PG classification | NA |
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