| Gene Information | |
|---|---|
| Gene Name | DDX3Y |
| Organism | Homo sapiens (Human) |
| Gene Length | 660 |
| Protein Names | ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000067048 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O15523 |
| Gene Card | DDX3Y |
| Uniprot ID | O15523 |
| Pfam | PF00270; PF00271 |
| In ASD | no |
| Allosteric Prediction | no (-0.506475171) |
| Ortholog in Animals | Alpaca_ DDX3Y ( ortholog_one2one ) Dog_ DDX3Y ( ortholog_one2one ) Macaque_ DDX3Y ( ortholog_one2one ) Mouse_ Ddx3y ( ortholog_one2one ) Rat_ Ddx3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46, DDX3X |
| Tissue | NA |
| Tissue Specificity | Widely expressed at the mRNA level, with highest levels in testis (PubMed:9381176). Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes (PubMed:15294876). {ECO:0000269|PubMed:15294876, ECO:0000269|PubMed:9381176}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15294876, ECO:0000269|PubMed:15383328}. Nucleus {ECO:0000269|PubMed:15383328}. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner. |
| Mouse PG classification | NA |
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