Gene Information
Gene NamePDCD8
OrganismHomo sapiens (Human)
Gene Length613
Protein NamesApoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO95831
Gene CardAIFM1
Uniprot IDO95831
PfamPF14721; PF07992
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in all tested tissues (PubMed:16644725). Detected in muscle and skin fibroblasts (at protein level) (PubMed:23217327). Expressed in osteoblasts (at protein level) (PubMed:28842795). {ECO:0000269|PubMed:16644725, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:28842795}.;
[Isoform 3]: Brain specific. {ECO:0000269|PubMed:20111043}.;
[Isoform 4]: Expressed in all tested tissues except brain. {ECO:0000269|PubMed:16644725}.;
[Isoform 5]: Isoform 5 is frequently down-regulated in human cancers. {ECO:0000269|PubMed:16365034}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.001000(Mouse);0.001578(Rat);0.011765(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1M6I  (X-ray  1.80A  )  4BUR  (X-ray  2.88A  )  4BV6  (X-ray  1.80A  )  4FDC  (X-ray  2.40A  )  4LII  (X-ray  1.88A  )  5FMH  (X-ray  1.80A  )  5FS6  (X-ray  1.90A  )  5FS7  (X-ray  1.85A  )  5FS8  (X-ray  1.40A  )  5FS9  (X-ray  1.75A  )  5KVH  (X-ray  2.27A  )  5KVI  (X-ray  2.00A  ) 
DBSNP rs387906500  rs377527583  rs1202786652  rs1202786652  rs1603225138  rs863225432  rs1603224817  rs1603224226  rs1603223152  rs184474885  rs724160026  rs724160021  rs724160020  rs1223488720  rs863225431  rs724160022  rs281864468  rs724160023 
Subcellular location [CC]Mitochondrion intermembrane space {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:26004228}. Mitochondrion inner membrane. Cytoplasm {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:33168626}. Nucleus {ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:33168626}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17094969}. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). Translocation into the nucleus is promoted by interaction with (auto-poly-ADP-ribosylated) processed form of PARP1 (PubMed:33168626). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:15775970, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:33168626}.;
[Isoform 3]: Mitochondrion intermembrane space {ECO:0000269|PubMed:20111043}. Mitochondrion inner membrane {ECO:0000269|PubMed:20111043}. Note=Has a stronger membrane anchorage than isoform 1. {ECO:0000269|PubMed:20111043}.;
[Isoform 4]: Mitochondrion {ECO:0000269|PubMed:16644725}. Cytoplasm, cytosol {ECO:0000269|PubMed:16644725}. Note=In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. {ECO:0000269|PubMed:16644725}.;
[Isoform 5]: Cytoplasm {ECO:0000269|PubMed:16365034}.
Mouse PG classificationNA
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