Gene Information
Gene NameDDX28
OrganismHomo sapiens (Human)
Gene Length540
Protein NamesProbable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28)
Target NameNA
Target TypeNA
Gene Age18 ( ENSG00000182810 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NUL7
Gene CardDDX28
Uniprot IDQ9NUL7
PfamPF00270; PF00271
In ASDno
Allosteric Predictionno (-1.754020806)
Ortholog in AnimalsAlpaca_ DDX28 ( ortholog_one2one )
Dog_ DDX28 ( ortholog_one2one )
GuineaPig_ DDX28 ( ortholog_one2one )
Macaque_ DDX28 ( ortholog_one2one )
Mouse_ Ddx28 ( ortholog_one2one )
Pig_ DDX28 ( ortholog_one2one )
Rat_ Ddx28 ( ortholog_one2one )
Rabbit_ DDX28 ( ortholog_one2one )
OhnologsNA
ParalogsDDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46
TissueNA
Tissue SpecificityExpressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate. {ECO:0000269|PubMed:11350955}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001516(Rat);0.03(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7OI6  (EM  5.70A 
DBSNP rs237831 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11350955, ECO:0000269|PubMed:25683708}. Mitochondrion {ECO:0000269|PubMed:11350955}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:25683715}. Mitochondrion matrix {ECO:0000269|PubMed:25683708}. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683708, ECO:0000269|PubMed:25683715}.
Mouse PG classificationNA
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