| Gene Information | |
|---|---|
| Gene Name | RNASE3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 160 |
| Protein Names | Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3) |
| Target Name | eosinophil cationic protein |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000169397 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P12724 |
| Gene Card | RNASE3 |
| Uniprot ID | P12724 |
| Pfam | PF00074 |
| In ASD | no |
| Allosteric Prediction | yes (0.055148529) |
| Ortholog in Animals | Mouse_ Ear1 ( ortholog_many2many ) Mouse_ Ear14 ( ortholog_many2many ) Mouse_ Ear10 ( ortholog_many2many ) Mouse_ Ear2 ( ortholog_many2many ) Mouse_ Rnase2a ( ortholog_many2many ) Mouse_ Rnase2b ( ortholog_many2many ) Mouse_ Ear6 ( ortholog_many2many ) Rat_ Ear1 ( ortholog_many2many ) Rat_ Rnase3 ( ortholog_many2many ) Rat_ Rnase17 ( ortholog_many2many ) Rat_ Rnase2 ( ortholog_many2many ) Rabbit_ RAF2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | RNASE2, RNASE10, RNASE9, RNASE6, RNASE1, RNASE11, ANG, RNASE4, RNASE12, RNASE13, RNASE8, RNASE7 |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DYT (X-ray 1.75A ) 1H1H (X-ray 2.00A ) 1QMT (X-ray 2.40A ) 2KB5 (NMR - ) 2LVZ (NMR - ) 4A2O (X-ray 1.69A ) 4A2Y (X-ray 1.70A ) 4OWZ (X-ray 1.47A ) 4OXB (X-ray 1.50A ) 4OXF (X-ray 1.50A ) 4X08 (X-ray 1.34A ) |
| DBSNP | rs151169198 rs2073342 rs12147890 |
| Subcellular location [CC] | Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus. |
| Mouse PG classification | NA |
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