| Gene Information | |
|---|---|
| Gene Name | MAP4K3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) |
| Target Name | mitogen-activated protein kinase kinase kinase kinase 3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000011566 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IVH8 |
| Gene Card | MAP4K3 |
| Uniprot ID | Q8IVH8 |
| Pfam | PF00780; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.270277693) |
| Ortholog in Animals | Alpaca_ MAP4K3 ( ortholog_one2one ) Dog_ MAP4K3 ( ortholog_one2one ) GuineaPig_ MAP4K3 ( ortholog_one2one ) Macaque_ MAP4K3 ( ortholog_one2one ) Mouse_ Map4k3 ( ortholog_one2one ) Pig_ MAP4K3 ( ortholog_one2one ) Rat_ Map4k3 ( ortholog_one2one ) Rabbit_ MAP4K3 ( ortholog_one2one ) |
| Ohnologs | MAP4K5, MAP4K1, MAP4K2 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. {ECO:0000269|PubMed:9275185}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5J5T (X-ray 2.85A ) |
| DBSNP | rs35957290 rs56317466 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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