| Gene Information | |
|---|---|
| Gene Name | IL1R2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)] |
| Target Name | interleukin 1 receptor type 2 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000115590 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P27930 |
| Gene Card | IL1R2 |
| Uniprot ID | P27930 |
| Pfam | PF00047; PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-0.064791851) |
| Ortholog in Animals | Alpaca_ IL1R2 ( ortholog_one2one ) Dog_ IL1R2 ( ortholog_one2one ) GuineaPig_ IL1R2 ( ortholog_one2one ) Macaque_ IL1R2 ( ortholog_one2one ) Mouse_ Il1r2 ( ortholog_one2one ) Pig_ IL1R2 ( ortholog_one2one ) Rat_ Il1r2 ( ortholog_one2one ) Rabbit_ IL1R2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LAG3, IL1R1, IL1RL1, IL1RL2, IL18R1, SIGIRR, IL18RAP, IL1RAPL1, IL1RAPL2, IL1RAP |
| Tissue | whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3O4O (X-ray 3.30A ) |
| DBSNP | rs28385682 rs3218976 |
| Subcellular location [CC] | [Isoform Short]: Secreted {ECO:0000269|PubMed:8702856}.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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