| Gene Information | |
|---|---|
| Gene Name | DDX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000079785 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q92499 |
| Gene Card | DDX1 |
| Uniprot ID | Q92499 |
| Pfam | PF00270; PF00271; PF00622 |
| In ASD | no |
| Allosteric Prediction | no (-0.395879684) |
| Ortholog in Animals | Alpaca_ DDX1 ( ortholog_one2one ) Dog_ DDX1 ( ortholog_one2one ) Macaque_ DDX1 ( ortholog_one2one ) Mouse_ Ddx1 ( ortholog_one2one ) Pig_ DDX1 ( ortholog_one2one ) Rat_ Ddx1 ( ortholog_one2one ) Rabbit_ DDX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX6, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | NA |
| Tissue Specificity | Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord. {ECO:0000269|PubMed:7689221}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002024(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4XW3 (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VR5}. Mitochondrion {ECO:0000250|UniProtKB:Q91VR5}. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). Colocalizes in the cytosol with DDX21, DHX36 and TICAM1. Colocalizes in the mitochondria with TICAM1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) stimulation (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:24608264}.; Cytoplasm {ECO:0000269|PubMed:20573827}. Note=(Microbial infection) Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells (PubMed:20573827). Required for proper localization of HIV-1 Rev (PubMed:15567440). {ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:20573827}. |
| Mouse PG classification | NA |
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