Gene Information
Gene NameDDR1
OrganismHomo sapiens (Human)
Gene Length913
Protein NamesEpithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Target Nameepithelial discoidin domain-containing receptor 1
Target TypeNA
Gene Age3 ( ENSG00000137332 )
454 ( ENSG00000204580 )
3 ( ENSG00000215522 )
3 ( ENSG00000223680 )
3 ( ENSG00000229767 )
3 ( ENSG00000230456 )
3 ( ENSG00000234078 )
Evolutionary StageEumetazoa
AlphaFoldDBQ08345
Gene CardDDR1
Uniprot IDQ08345
PfamPF00754; PF07714
In ASDyes
Allosteric Predictionyes (0.927102533)
Ortholog in AnimalsAlpaca_ DDR1 ( ortholog_one2one )
Dog_ DDR1 ( ortholog_one2one )
GuineaPig_ DDR1 ( ortholog_one2one )
Macaque_ DDR1 ( ortholog_one2one )
Mouse_ Ddr1 ( ortholog_one2one )
Pig_ DDR1 ( ortholog_one2one )
Rat_ Ddr1 ( ortholog_one2one )
Rabbit_ DDR1 ( ortholog_one2one )
OhnologsDDR2
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityDetected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. {ECO:0000269|PubMed:7845687, ECO:0000269|PubMed:7848919, ECO:0000269|PubMed:8247543}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3ZOS  (X-ray  1.92A  )  4AG4  (X-ray  2.80A  )  4BKJ  (X-ray  1.70A  )  4CKR  (X-ray  2.20A  )  5BVK  (X-ray  2.29A  )  5BVN  (X-ray  2.21A  )  5BVO  (X-ray  1.98A  )  5BVW  (X-ray  1.94A  )  5FDP  (X-ray  2.25A  )  5FDX  (X-ray  2.65A  )  5SAU  (X-ray  1.80A  )  5SAV  (X-ray  1.76A  )  5SAW  (X-ray  1.60A  )  5SAX  (X-ray  1.90A  )  5SAY  (X-ray  2.19A  )  5SAZ  (X-ray  1.80A  )  5SB0  (X-ray  1.97A  )  5SB1  (X-ray  1.53A  )  5SB2  (X-ray  1.60A  )  6BRJ  (X-ray  2.23A  )  6BSD  (X-ray  2.61A  )  6FEW  (X-ray  1.44A  )  6FEX  (X-ray  1.29A  )  6FIL  (X-ray  1.73A  )  6FIN  (X-ray  1.67A  )  6FIO  (X-ray  1.99A  )  6FIQ  (X-ray  1.79A  )  6GWR  (X-ray  2.07A  )  6HP9  (X-ray  1.96A  )  6Y23  (X-ray  2.58A  )  7BCM  (X-ray  2.30A  )  7BE6  (X-ray  1.87A  )  7FEH  (X-ray  1.61A  ) 
DBSNP rs55901302  rs34544756  rs55980643  rs56231803  rs56024191  rs2524235 
Subcellular location [CC][Isoform 1]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 2]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 3]: Secreted {ECO:0000305}.;
[Isoform 4]: Cell membrane;
Single-pass type I membrane protein.
Mouse PG classificationNA
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