| Gene Information | |
|---|---|
| Gene Name | DDIT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 232 |
| Protein Names | DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1) |
| Target Name | rtp801 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000168209 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NX09 |
| Gene Card | DDIT4 |
| Uniprot ID | Q9NX09 |
| Pfam | PF07809 |
| In ASD | no |
| Allosteric Prediction | yes (0.128084133) |
| Ortholog in Animals | Alpaca_ DDIT4 ( ortholog_one2one ) Dog_ DDIT4 ( ortholog_one2one ) GuineaPig_ DDIT4 ( ortholog_one2one ) Macaque_ DDIT4 ( ortholog_one2one ) Mouse_ Ddit4 ( ortholog_one2one ) Pig_ DDIT4 ( ortholog_one2one ) Rat_ Ddit4 ( ortholog_one2one ) Rabbit_ DDIT4 ( ortholog_one2one ) |
| Ohnologs | DDIT4L |
| Paralogs | DDIT4L |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3LQ9 (X-ray 2.00A ) 7MOP (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12453409}. |
| Mouse PG classification | NA |
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