| Gene Information | |
|---|---|
| Gene Name | UBA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 640 |
| Protein Names | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000126261 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBT2 |
| Gene Card | UBA2 |
| Uniprot ID | Q9UBT2 |
| Pfam | PF00899; PF14732; PF16195 |
| In ASD | yes |
| Allosteric Prediction | no (-0.497161255) |
| Ortholog in Animals | Alpaca_ UBA2 ( ortholog_one2one ) Dog_ UBA2 ( ortholog_one2one ) GuineaPig_ UBA2 ( ortholog_one2one ) Macaque_ UBA2 ( ortholog_one2one ) Mouse_ Uba2 ( ortholog_one2one ) Rat_ Uba2 ( ortholog_one2one ) Rabbit_ UBA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, UBA3, NAE1, UBA6, UBA1, UBA5, MOCS3, ATG7, SAE1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.021622(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Y8Q (X-ray 2.25A ) 1Y8R (X-ray 2.75A ) 2PX9 (NMR - ) 3KYC (X-ray 2.45A ) 3KYD (X-ray 2.61A ) 4W5V (X-ray 2.50A ) 5FQ2 (X-ray 2.20A ) 6CWY (X-ray 2.46A ) 6CWZ (X-ray 3.10A ) 6XOG (X-ray 1.98A ) 6XOH (X-ray 2.23A ) 6XOI (X-ray 2.00A ) |
| DBSNP | rs1043062 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention. |
| Mouse PG classification | NA |
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