Gene Information
Gene NameDDH1
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesAldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP42330
Gene CardAKR1C3
Uniprot IDP42330
PfamPF00248
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. High expression in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1RY0  (X-ray  1.69A  1RY8  (X-ray  1.69A  1S1P  (X-ray  1.20A  1S1R  (X-ray  2.00A  1S2A  (X-ray  1.70A  1S2C  (X-ray  1.80A  1XF0  (X-ray  2.00A  1ZQ5  (X-ray  1.30A  2F38  (X-ray  2.00A  2FGB  (X-ray  1.35A  3R43  (X-ray  2.00A  3R58  (X-ray  2.30A  3R6I  (X-ray  1.95A  3R7M  (X-ray  2.10A  3R8G  (X-ray  1.80A  3R8H  (X-ray  1.90A  3R94  (X-ray  2.01A  3UFY  (X-ray  1.90A  3UG8  (X-ray  1.73A  3UGR  (X-ray  1.65A  3UWE  (X-ray  1.68A  4DBS  (X-ray  1.85A  4DBU  (X-ray  2.53A  4DBW  (X-ray  1.80A  4DZ5  (X-ray  1.70A  4FA3  (X-ray  2.20A  4FAL  (X-ray  2.00A  4FAM  (X-ray  2.00A  4H7C  (X-ray  1.97A  4HMN  (X-ray  2.40A  4WDT  (X-ray  1.50A  4WDU  (X-ray  1.70A  4WDW  (X-ray  1.94A  4WDX  (X-ray  1.64A  4WRH  (X-ray  1.60A  4XVD  (X-ray  2.81A  4XVE  (X-ray  1.55A  4YVV  (X-ray  2.30A  4YVX  (X-ray  2.30A  4ZFC  (X-ray  2.00A  5HNT  (X-ray  2.00A  5HNU  (X-ray  2.00A  6A7B  (X-ray  2.37A  6F2U  (X-ray  1.88A  6F78  (X-ray  1.30A  6GXK  (X-ray  1.70A  7C7F  (X-ray  1.70A  7C7G  (X-ray  1.86A  7C7H  (X-ray  1.86A 
DBSNP rs12529  rs35961894  rs11551177  rs35575889  rs1131132  rs34186955 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:10622721}.
Mouse PG classificationNA
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