Gene Information | |
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Gene Name | DDH1 |
Organism | Homo sapiens (Human) |
Gene Length | 323 |
Protein Names | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | P42330 |
Gene Card | AKR1C3 |
Uniprot ID | P42330 |
Pfam | PF00248 |
In ASD | no |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. High expression in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate. {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1RY0 (X-ray 1.69A ) 1RY8 (X-ray 1.69A ) 1S1P (X-ray 1.20A ) 1S1R (X-ray 2.00A ) 1S2A (X-ray 1.70A ) 1S2C (X-ray 1.80A ) 1XF0 (X-ray 2.00A ) 1ZQ5 (X-ray 1.30A ) 2F38 (X-ray 2.00A ) 2FGB (X-ray 1.35A ) 3R43 (X-ray 2.00A ) 3R58 (X-ray 2.30A ) 3R6I (X-ray 1.95A ) 3R7M (X-ray 2.10A ) 3R8G (X-ray 1.80A ) 3R8H (X-ray 1.90A ) 3R94 (X-ray 2.01A ) 3UFY (X-ray 1.90A ) 3UG8 (X-ray 1.73A ) 3UGR (X-ray 1.65A ) 3UWE (X-ray 1.68A ) 4DBS (X-ray 1.85A ) 4DBU (X-ray 2.53A ) 4DBW (X-ray 1.80A ) 4DZ5 (X-ray 1.70A ) 4FA3 (X-ray 2.20A ) 4FAL (X-ray 2.00A ) 4FAM (X-ray 2.00A ) 4H7C (X-ray 1.97A ) 4HMN (X-ray 2.40A ) 4WDT (X-ray 1.50A ) 4WDU (X-ray 1.70A ) 4WDW (X-ray 1.94A ) 4WDX (X-ray 1.64A ) 4WRH (X-ray 1.60A ) 4XVD (X-ray 2.81A ) 4XVE (X-ray 1.55A ) 4YVV (X-ray 2.30A ) 4YVX (X-ray 2.30A ) 4ZFC (X-ray 2.00A ) 5HNT (X-ray 2.00A ) 5HNU (X-ray 2.00A ) 6A7B (X-ray 2.37A ) 6F2U (X-ray 1.88A ) 6F78 (X-ray 1.30A ) 6GXK (X-ray 1.70A ) 7C7F (X-ray 1.70A ) 7C7G (X-ray 1.86A ) 7C7H (X-ray 1.86A ) |
DBSNP | rs12529 rs35961894 rs11551177 rs35575889 rs1131132 rs34186955 |
Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10622721}. |
Mouse PG classification | NA |
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