| Gene Information | |
|---|---|
| Gene Name | DDC |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) |
| Target Name | aromatic-l-amino-acid decarboxylase |
| Target Type | Successful target |
| Gene Age | 1064 ( ENSG00000132437 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P20711 |
| Gene Card | DDC |
| Uniprot ID | P20711 |
| Pfam | PF00282 |
| In ASD | no |
| Allosteric Prediction | yes (0.963652131) |
| Ortholog in Animals | Alpaca_ DDC ( ortholog_one2one ) Dog_ DDC ( ortholog_one2one ) GuineaPig_ DDC ( ortholog_one2one ) Macaque_ DDC ( ortholog_one2one ) Mouse_ Ddc ( ortholog_one2one ) Pig_ DDC ( ortholog_one2one ) Rat_ Ddc ( ortholog_one2one ) Rabbit_ DDC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SGPL1, CSAD, PDXDC1, HDC, GAD1, GADL1, GAD2 |
| Tissue | duodenum, kidney, small.intestine, cortex.of.kidney, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | [Isoform 2]: High expression in kidney. {ECO:0000269|PubMed:15532536}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RBF (X-ray 2.90A ) 3RBL (X-ray 3.24A ) 3RCH (X-ray 2.80A ) |
| DBSNP | rs6264 rs780542462 rs11575292 rs137853211 rs137853207 rs137853210 rs6262 rs6263 rs11575377 rs11575376 rs137853208 rs137853212 rs137853209 rs201951824 rs11575542 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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