| Gene Information | |
|---|---|
| Gene Name | DDB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000134574 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q92466 |
| Gene Card | DDB2 |
| Uniprot ID | Q92466 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.271144721) |
| Ortholog in Animals | Alpaca_ DDB2 ( ortholog_one2one ) Dog_ DDB2 ( ortholog_one2one ) GuineaPig_ DDB2 ( ortholog_one2one ) Mouse_ Ddb2 ( ortholog_one2one ) Pig_ DDB2 ( ortholog_one2one ) Rat_ Ddb2 ( ortholog_one2one ) Rabbit_ DDB2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. {ECO:0000269|PubMed:14751237}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002363(Rat);0.026923(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EI4 (X-ray 3.30A ) 3I7L (X-ray 2.80A ) 4E54 (X-ray 2.85A ) 4E5Z (X-ray 3.22A ) 6R8Y (EM 4.30A ) 6R8Z (EM 3.90A ) 6R90 (EM 4.50A ) 6R91 (EM 4.10A ) 6R92 (EM 4.80A ) |
| DBSNP | rs4647750 rs121434639 rs121434640 rs4647751 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10777490, ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11705987, ECO:0000269|PubMed:12944386, ECO:0000269|PubMed:14751237, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16713579, ECO:0000269|PubMed:17635991, ECO:0000269|PubMed:18593899}. Chromosome {ECO:0000269|PubMed:32789493}. Note=Accumulates at sites of DNA damage following UV irradiation. {ECO:0000269|PubMed:32789493}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |