| Gene Information | |
|---|---|
| Gene Name | DDB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1140 |
| Protein Names | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000167986 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16531 |
| Gene Card | DDB1 |
| Uniprot ID | Q16531 |
| Pfam | PF03178; PF10433 |
| In ASD | no |
| Allosteric Prediction | yes (0.442585376) |
| Ortholog in Animals | Alpaca_ DDB1 ( ortholog_one2one ) Dog_ DDB1 ( ortholog_one2one ) GuineaPig_ DDB1 ( ortholog_one2one ) Macaque_ DDB1 ( ortholog_one2one ) Mouse_ Ddb1 ( ortholog_one2one ) Pig_ DDB1 ( ortholog_one2one ) Rat_ Ddb1 ( ortholog_one2one ) Rabbit_ DDB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SF3B3, CPSF1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002874(Rat);0.101026(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B5L (X-ray 2.85A ) 2B5M (X-ray 2.92A ) 2B5N (X-ray 2.80A ) 2HYE (X-ray 3.10A ) 3E0C (X-ray 2.41A ) 3EI1 (X-ray 2.80A ) 3EI2 (X-ray 2.60A ) 3EI3 (X-ray 2.30A ) 3EI4 (X-ray 3.30A ) 3I7H (X-ray 2.90A ) 3I7K (X-ray 2.80A ) 3I7L (X-ray 2.80A ) 3I7N (X-ray 2.80A ) 3I7O (X-ray 2.80A ) 3I7P (X-ray 3.00A ) 3I89 (X-ray 3.00A ) 3I8C (X-ray 2.80A ) 3I8E (X-ray 3.40A ) 4A08 (X-ray 3.00A ) 4A09 (X-ray 3.10A ) 4A0A (X-ray 3.60A ) 4A0B (X-ray 3.80A ) 4A0K (X-ray 5.93A ) 4A0L (X-ray 7.40A ) 4A11 (X-ray 3.31A ) 4CI1 (X-ray 2.98A ) 4CI2 (X-ray 2.95A ) 4CI3 (X-ray 3.50A ) 4E54 (X-ray 2.85A ) 4E5Z (X-ray 3.22A ) 4TZ4 (X-ray 3.01A ) 5FQD (X-ray 2.45A ) 5HXB (X-ray 3.60A ) 5JK7 (X-ray 3.49A ) 5V3O (X-ray 3.20A ) 6BN7 (X-ray 3.50A ) 6BN8 (X-ray 3.99A ) 6BN9 (X-ray 4.38A ) 6BNB (X-ray 6.34A ) 6BOY (X-ray 3.33A ) 6DSZ (X-ray 3.09A ) 6FCV (X-ray 2.92A ) 6H0F (X-ray 3.25A ) 6H0G (X-ray 4.25A ) 6PAI (X-ray 2.90A ) 6Q0R (X-ray 2.90A ) 6Q0V (X-ray 2.90A ) 6Q0W (X-ray 2.90A ) 6R8Y (EM 4.30A ) 6R8Z (EM 3.90A ) 6R90 (EM 4.50A ) 6R91 (EM 4.10A ) 6R92 (EM 4.80A ) 6SJ7 (EM 3.54A ) 6TD3 (X-ray 3.46A ) 6UD7 (X-ray 2.30A ) 6UE5 (X-ray 2.61A ) 6UML (X-ray 3.58A ) 6XK9 (X-ray 3.64A ) 6ZUE (X-ray 3.09A ) 6ZX9 (X-ray 2.52A ) 7LPS (X-ray 3.78A ) 7OKQ (EM 8.40A ) 7OO3 (EM 2.80A ) 7OOB (EM 2.70A ) 7OOP (EM 2.90A ) 7OPC (EM 3.00A ) 7OPD (EM 3.00A ) 7UKN (X-ray 2.90A ) 7V7B (EM 4.20A ) 7V7C (EM 3.70A ) 8CVP (EM 3.40A ) 8D7U (EM 3.10A ) 8D7V (EM 3.20A ) 8D7W (EM 3.10A ) 8D7X (EM 3.40A ) 8D7Y (EM 3.40A ) 8D7Z (EM 3.10A ) 8D80 (EM 3.60A ) 8D81 (EM 3.90A ) |
| DBSNP | rs28720299 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459, ECO:0000269|PubMed:18593899}. Nucleus {ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459, ECO:0000269|PubMed:18593899}. Note=Primarily cytoplasmic (PubMed:10777491, PubMed:11673459). Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage (PubMed:10777491, PubMed:11673459). {ECO:0000269|PubMed:10777491, ECO:0000269|PubMed:11673459}. |
| Mouse PG classification | NA |
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