| Gene Information | |
|---|---|
| Gene Name | DDAH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 285 |
| Protein Names | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein) |
| Target Name | n(g),n(g)-dimethylarginine dimethylaminohydrolase 2 |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000206395 ) 454 ( ENSG00000213722 ) 3 ( ENSG00000225635 ) 3 ( ENSG00000226634 ) 3 ( ENSG00000227317 ) 3 ( ENSG00000228128 ) 3 ( ENSG00000233076 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O95865 |
| Gene Card | DDAH2 |
| Uniprot ID | O95865 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.563168912) |
| Ortholog in Animals | Alpaca_ DDAH2 ( ortholog_one2one ) Dog_ DDAH2 ( ortholog_one2one ) GuineaPig_ DDAH2 ( ortholog_one2one ) Macaque_ DDAH2 ( ortholog_one2one ) Mouse_ Ddah2 ( ortholog_one2one ) Pig_ DDAH2 ( ortholog_one2one ) Rat_ Ddah2 ( ortholog_one2one ) Rabbit_ DDAH2 ( ortholog_one2one ) |
| Ohnologs | DDAH1 |
| Paralogs | DDAH1 |
| Tissue | NA |
| Tissue Specificity | Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269|PubMed:10493931}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21898353}. Mitochondrion {ECO:0000269|PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes. |
| Mouse PG classification | NA |
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