Gene Information
Gene NameYAP1
OrganismHomo sapiens (Human)
Gene Length504
Protein NamesTranscriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000137693 )
Evolutionary StageEumetazoa
AlphaFoldDBP46937
Gene CardYAP1
Uniprot IDP46937
PfamPF00397
In ASDno
Allosteric Predictionyes (0.367558964)
Ortholog in AnimalsAlpaca_ YAP1 ( ortholog_one2one )
Dog_ YAP1 ( ortholog_one2one )
GuineaPig_ YAP1 ( ortholog_one2one )
Macaque_ YAP1 ( ortholog_one2one )
Mouse_ Yap1 ( ortholog_one2one )
Pig_ YAP1 ( ortholog_one2one )
Rat_ Yap1 ( ortholog_one2one )
Rabbit_ YAP1 ( ortholog_one2one )
OhnologsWWTR1
ParalogsWWTR1
TissueNA
Tissue SpecificityIncreased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). {ECO:0000269|PubMed:16461361, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:7782338}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.008084(Rat);0.054334(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1JMQ  (NMR  -  )  1K5R  (NMR  -  )  1K9Q  (NMR  -  )  1K9R  (NMR  -  )  2LAW  (NMR  -  )  2LAX  (NMR  -  )  2LAY  (NMR  -  )  2LTV  (NMR  -  )  2LTW  (NMR  -  )  3KYS  (X-ray  2.80A  )  3MHR  (X-ray  1.15A  )  4RE1  (X-ray  2.20A  )  4REX  (X-ray  1.60A  )  5OAQ  (X-ray  1.95A  )  5YDX  (NMR  -  )  5YDY  (NMR  -  )  6G6X  (X-ray  1.13A  )  6G8I  (X-ray  1.60A  )  6G8J  (X-ray  1.47A  )  6G8K  (X-ray  1.25A  )  6G8L  (X-ray  1.37A  )  6G8P  (X-ray  1.90A  )  6G8Q  (X-ray  1.85A  )  6GE3  (X-ray  1.85A  )  6GE4  (X-ray  1.97A  )  6GE5  (X-ray  2.05A  )  6GE6  (X-ray  1.80A  )  6GEC  (X-ray  1.70A  )  6GEE  (X-ray  1.96A  )  6GEG  (X-ray  2.23A  )  6GEI  (X-ray  1.65A  )  6GEK  (X-ray  2.28A  )  6HIK  (X-ray  1.65A  )  6HIL  (X-ray  2.30A  )  6Q2X  (X-ray  2.10A  )  7O07  (X-ray  1.20A  ) 
DBSNP rs1162286204  rs376161041  rs777949318 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865}. Nucleus {ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:28169360, ECO:0000269|PubMed:30447097}. Note=Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865}.
Mouse PG classificationLPG
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