| Gene Information | |
|---|---|
| Gene Name | DCX |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000077279 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43602 |
| Gene Card | DCX |
| Uniprot ID | O43602 |
| Pfam | PF03607 |
| In ASD | no |
| Allosteric Prediction | no (-1.000068768) |
| Ortholog in Animals | Alpaca_ DCX ( ortholog_one2one ) Dog_ DCX ( ortholog_one2one ) GuineaPig_ DCX ( ortholog_one2one ) Macaque_ DCX ( ortholog_one2one ) Mouse_ Dcx ( ortholog_one2one ) Pig_ DCX ( ortholog_one2one ) Rat_ Dcx ( ortholog_one2one ) Rabbit_ DCX ( ortholog_one2one ) |
| Ohnologs | DCLK1, DCLK2 |
| Paralogs | MAPKAPK3, MAPKAPK5, MKNK1, MAPKAPK2, MKNK2, CAMK4 |
| Tissue | brain |
| Tissue Specificity | Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MJD (NMR - ) 2BQQ (X-ray 2.20A ) 2XRP (EM 8.20A ) 4ATU (EM 8.30A ) 5IKC (X-ray 2.06A ) 5IN7 (X-ray 2.48A ) 5IO9 (X-ray 1.30A ) 5IOI (X-ray 2.40A ) 5IP4 (X-ray 1.81A ) 6FNZ (X-ray 2.23A ) 6REV (EM 3.80A ) 6RF2 (EM 4.20A ) 6RF8 (EM 3.80A ) 6RFD (EM 3.90A ) |
| DBSNP | rs587783521 rs104894783 rs587783523 rs122457137 rs122457137 rs104894779 rs104894786 rs104894784 rs104894784 rs104894785 rs587783537 rs104894781 rs587783558 rs587783559 rs587783562 rs587783566 rs104894780 rs56030372 rs587783568 rs587783570 rs104894782 rs587783574 rs1324159050 rs587783585 rs398124557 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7}. |
| Mouse PG classification | NA |
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