| Gene Information | |
|---|---|
| Gene Name | DCTN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1278 |
| Protein Names | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000204843 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14203 |
| Gene Card | DCTN1 |
| Uniprot ID | Q14203 |
| Pfam | PF01302; PF12455 |
| In ASD | no |
| Allosteric Prediction | no (-0.021909202) |
| Ortholog in Animals | Alpaca_ DCTN1 ( ortholog_one2one ) Dog_ DCTN1 ( ortholog_one2one ) GuineaPig_ DCTN1 ( ortholog_one2one ) Macaque_ DCTN1 ( ortholog_one2one ) Mouse_ Dctn1 ( ortholog_one2one ) Pig_ DCTN1 ( ortholog_one2one ) Rat_ Dctn1 ( ortholog_one2one ) Rabbit_ DCTN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CLIP4, CLIP1, CLIP3, CLIP2 |
| Tissue | NA |
| Tissue Specificity | Brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TXQ (X-ray 1.80A ) 2COY (NMR - ) 2HKN (X-ray 1.87A ) 2HKQ (X-ray 1.86A ) 2HL3 (X-ray 2.03A ) 2HL5 (X-ray 1.93A ) 2HQH (X-ray 1.80A ) 3E2U (X-ray 2.60A ) 3TQ7 (X-ray 2.30A ) |
| DBSNP | rs886039227 rs121909342 rs67586389 rs67586389 rs72466485 rs72466486 rs72466487 rs886039229 rs55862001 rs13420401 rs17721059 rs121909343 rs765819985 rs121909344 rs121909345 rs72466496 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17828277}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:25774020}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25774020}. Nucleus envelope {ECO:0000269|PubMed:20679239}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22327364}. Note=Localizes to microtubule plus ends (PubMed:17828277, PubMed:22777741, PubMed:25774020). Localizes preferentially to the ends of tyrosinated microtubules (PubMed:26972003). Localization at centrosome is regulated by SLK-dependent phosphorylation (PubMed:23985322). Localizes to centrosome in a PARKDA-dependent manner (PubMed:20719959). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061). PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (PubMed:20679239). {ECO:0000269|PubMed:17828277, ECO:0000269|PubMed:20679239, ECO:0000269|PubMed:20719959, ECO:0000269|PubMed:22777741, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23985322, ECO:0000269|PubMed:25774020, ECO:0000269|PubMed:26972003}. |
| Mouse PG classification | HPG |
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