| Gene Information | |
|---|---|
| Gene Name | DCP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1306 |
| Protein Names | Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P12821 |
| Gene Card | ACE |
| Uniprot ID | P12821 |
| Pfam | PF01401 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15671045}.; [Isoform Testis-specific]: Specifically expressed in spermatocytes and adult testis. {ECO:0000269|PubMed:2547653, ECO:0000269|PubMed:2554286}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1O86 (X-ray 2.00A ) 1O8A (X-ray 2.00A ) 1UZE (X-ray 1.82A ) 1UZF (X-ray 2.00A ) 2C6F (X-ray 3.01A ) 2C6N (X-ray 3.00A ) 2IUL (X-ray 2.01A ) 2IUX (X-ray 2.80A ) 2OC2 (X-ray 2.25A ) 2XY9 (X-ray 1.97A ) 2XYD (X-ray 2.15A ) 2YDM (X-ray 2.44A ) 3BKK (X-ray 2.17A ) 3BKL (X-ray 2.18A ) 3L3N (X-ray 2.30A ) 3NXQ (X-ray 1.99A ) 4APH (X-ray 1.99A ) 4APJ (X-ray 2.60A ) 4BXK (X-ray 2.20A ) 4BZR (X-ray 1.84A ) 4BZS (X-ray 2.10A ) 4C2N (X-ray 2.59A ) 4C2O (X-ray 1.80A ) 4C2P (X-ray 1.99A ) 4C2Q (X-ray 2.40A ) 4C2R (X-ray 2.30A ) 4CA5 (X-ray 1.85A ) 4CA6 (X-ray 1.91A ) 4UFA (X-ray 1.80A ) 4UFB (X-ray 1.80A ) 5AM8 (X-ray 1.90A ) 5AM9 (X-ray 1.80A ) 5AMA (X-ray 1.80A ) 5AMB (X-ray 1.55A ) 5AMC (X-ray 1.65A ) 6EN5 (X-ray 1.75A ) 6EN6 (X-ray 1.80A ) 6F9R (X-ray 1.85A ) 6F9T (X-ray 1.60A ) 6F9U (X-ray 1.90A ) 6F9V (X-ray 1.69A ) 6H5W (X-ray 1.37A ) 6H5X (X-ray 1.80A ) 6QS1 (X-ray 1.80A ) 6TT1 (X-ray 1.80A ) 6TT3 (X-ray 1.70A ) 6TT4 (X-ray 1.80A ) 6ZPQ (X-ray 1.85A ) 6ZPT (X-ray 2.80A ) 6ZPU (X-ray 2.00A ) 7Q24 (X-ray 2.00A ) 7Q25 (X-ray 1.60A ) 7Q26 (X-ray 1.70A ) 7Q27 (X-ray 1.50A ) 7Q28 (X-ray 1.65A ) 7Q29 (X-ray 1.60A ) 7Q3Y (EM 4.34A ) 7Q49 (EM 3.72A ) 7Q4C (EM 4.08A ) 7Q4D (EM 3.78A ) 7Q4E (EM 3.63A ) 7Z6Z (X-ray 1.75A ) 7Z70 (X-ray 1.85A ) |
| DBSNP | rs13306087 rs12720754 rs3730025 rs4302 rs4303 rs4303 rs989500910 rs2229839 rs56394458 rs13306085 rs12720746 rs4314 rs12709426 rs13306091 rs3730043 rs4976 rs4977 rs12709442 rs121912703 rs4980 rs4364 rs4981 rs4317 rs4318 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12386153}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P09470}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:P09470}.; [Angiotensin-converting enzyme, soluble form]: Secreted {ECO:0000269|PubMed:10769174, ECO:0000269|PubMed:11274151, ECO:0000269|PubMed:7499427, ECO:0000269|PubMed:8253769}.; [Isoform Testis-specific]: Cell membrane {ECO:0000269|PubMed:1668266, ECO:0000269|PubMed:8626443}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:1668266}. Note=The testis-specific isoform can be cleaved before the transmembrane region, releasing a soluble form. {ECO:0000269|PubMed:1668266}. |
| Mouse PG classification | NA |
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