| Gene Information | |
|---|---|
| Gene Name | CRTC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 634 |
| Protein Names | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) |
| Target Name | creb-regulated transcription coactivator 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000105662 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UUV9 |
| Gene Card | CRTC1 |
| Uniprot ID | Q6UUV9 |
| Pfam | PF12886; PF12885; PF12884 |
| In ASD | no |
| Allosteric Prediction | no (-0.003777534) |
| Ortholog in Animals | Alpaca_ CRTC1 ( ortholog_one2one ) Dog_ CRTC1 ( ortholog_one2one ) GuineaPig_ CRTC1 ( ortholog_one2one ) Macaque_ CRTC1 ( ortholog_one2one ) Mouse_ Crtc1 ( ortholog_one2one ) Pig_ CRTC1 ( ortholog_one2one ) Rat_ Crtc1 ( ortholog_one2one ) |
| Ohnologs | CRTC3, CRTC2 |
| Paralogs | CRTC3, CRTC2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. {ECO:0000269|PubMed:14720503, ECO:0000269|PubMed:16980408}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7D8H (X-ray 2.42A ) 7D8P (X-ray 2.00A ) 7D9V (X-ray 2.21A ) |
| DBSNP | rs3746266 rs36070283 rs3746266 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}. |
| Mouse PG classification | NA |
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