| Gene Information | |
|---|---|
| Gene Name | DCD |
| Organism | Homo sapiens (Human) |
| Gene Length | 110 |
| Protein Names | Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1] |
| Target Name | dermcidin |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000161634 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P81605 |
| Gene Card | DCD |
| Uniprot ID | P81605 |
| Pfam | PF15291 |
| In ASD | no |
| Allosteric Prediction | yes (0.110662099) |
| Ortholog in Animals | Alpaca_ DCD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LACRT |
| Tissue | lower.leg.skin |
| Tissue Specificity | Specifically and constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml. {ECO:0000269|PubMed:11694882}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KSG (NMR - ) 2NDK (NMR - ) 2YMK (X-ray 2.49A ) 6SHK (X-ray 1.99A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11694882, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:25946035, ECO:0000269|PubMed:9736629}.; [Survival-promoting peptide]: Secreted {ECO:0000269|PubMed:9736629}.; [DCD-1]: Secreted {ECO:0000305|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Peripheral membrane protein {ECO:0000269|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Single-pass membrane protein {ECO:0000269|PubMed:23426625}. Note=The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. {ECO:0000269|PubMed:23426625}. |
| Mouse PG classification | NA |
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