| Gene Information | |
|---|---|
| Gene Name | DCC |
| Organism | Homo sapiens (Human) |
| Gene Length | 1447 |
| Protein Names | Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000187323 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43146 |
| Gene Card | DCC |
| Uniprot ID | P43146 |
| Pfam | PF00041; PF07679; PF06583 |
| In ASD | no |
| Allosteric Prediction | yes (0.331938959) |
| Ortholog in Animals | Alpaca_ DCC ( ortholog_one2one ) Dog_ DCC ( ortholog_one2one ) GuineaPig_ DCC ( ortholog_one2one ) Macaque_ DCC ( ortholog_one2one ) Mouse_ Dcc ( ortholog_one2one ) Pig_ DCC ( ortholog_one2one ) Rat_ Dcc ( ortholog_one2one ) Rabbit_ DCC ( ortholog_one2one ) |
| Ohnologs | NEO1 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | testis |
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. {ECO:0000269|PubMed:7926722}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2ED7 (NMR - ) 2ED8 (NMR - ) 2ED9 (NMR - ) 2EDB (NMR - ) 2EDD (NMR - ) 2EDE (NMR - ) 3AU4 (X-ray 1.90A ) 4URT (X-ray 3.10A ) 5X83 (X-ray 3.00A ) |
| DBSNP | rs9951523 rs121912967 rs2229080 rs1057519056 rs2271042 rs1555652216 rs199651452 rs775565634 rs2278339 rs1057519054 rs1057519055 rs1057519057 rs984274 rs2270950 rs1057519058 rs748112308 rs387906555 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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