| Gene Information | |
|---|---|
| Gene Name | DBT |
| Organism | Homo sapiens (Human) |
| Gene Length | 482 |
| Protein Names | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000137992 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P11182 |
| Gene Card | DBT |
| Uniprot ID | P11182 |
| Pfam | PF00198; PF00364; PF02817 |
| In ASD | no |
| Allosteric Prediction | no (-0.478072692) |
| Ortholog in Animals | Alpaca_ DBT ( ortholog_one2one ) Dog_ DBT ( ortholog_one2one ) GuineaPig_ DBT ( ortholog_one2one ) Macaque_ DBT ( ortholog_one2one ) Mouse_ Dbt ( ortholog_one2one ) Pig_ DBT ( ortholog_one2one ) Rat_ Dbt ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDHX, DLST, DLAT |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1K8M (NMR - ) 1K8O (NMR - ) 1ZWV (NMR - ) 2COO (NMR - ) 3RNM (X-ray 2.40A ) |
| DBSNP | rs121965001 rs121964999 rs12021720 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | HPG |
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