| Gene Information | |
|---|---|
| Gene Name | PDK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 407 |
| Protein Names | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII) |
| Target Name | [pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000005882 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15119 |
| Gene Card | PDK2 |
| Uniprot ID | Q15119 |
| Pfam | PF10436; PF02518 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999705053) |
| Ortholog in Animals | Alpaca_ PDK2 ( ortholog_one2one ) Dog_ PDK2 ( ortholog_one2one ) GuineaPig_ PDK2 ( ortholog_one2one ) Macaque_ PDK2 ( ortholog_one2one ) Mouse_ Pdk2 ( ortholog_one2one ) Pig_ PDK2 ( ortholog_one2one ) Rat_ Pdk2 ( ortholog_one2one ) |
| Ohnologs | PDK4, PDK1 |
| Paralogs | PDK4, PDK1, PDK3, BCKDK |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. {ECO:0000269|PubMed:7499431}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.01(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2BTZ (X-ray 2.20A ) 2BU2 (X-ray 2.40A ) 2BU5 (X-ray 2.35A ) 2BU6 (X-ray 2.40A ) 2BU7 (X-ray 2.40A ) 2BU8 (X-ray 2.50A ) 4MP2 (X-ray 1.75A ) 4MP7 (X-ray 1.80A ) 4MPC (X-ray 1.70A ) 4MPE (X-ray 1.95A ) 4MPN (X-ray 1.75A ) 4V25 (X-ray 2.60A ) 4V26 (X-ray 2.49A ) 5J6A (X-ray 2.04A ) 5J71 (X-ray 1.65A ) 5M4K (X-ray 2.60A ) 5M4M (X-ray 2.40A ) 5M4N (X-ray 2.60A ) 5M4P (X-ray 2.30A ) 6LIL (X-ray 1.93A ) 6LIN (X-ray 2.67A ) 6LIO (X-ray 1.76A ) 6TMP (X-ray 2.08A ) 6TMQ (X-ray 2.11A ) 6TMZ (X-ray 2.71A ) 6TN0 (X-ray 1.91A ) 6TN2 (X-ray 1.77A ) 7EA0 (X-ray 2.34A ) 7EAS (X-ray 1.97A ) 7EBH (X-ray 1.96A ) 7VBU (X-ray 1.89A ) 7VBV (X-ray 2.21A ) 7VBX (X-ray 2.60A ) |
| DBSNP | rs17855787 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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