| Gene Information | |
|---|---|
| Gene Name | DBI |
| Organism | Homo sapiens (Human) |
| Gene Length | 87 |
| Protein Names | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) |
| Target Name | acyl-coa-binding protein |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000155368 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P07108 |
| Gene Card | DBI |
| Uniprot ID | P07108 |
| Pfam | PF00887 |
| In ASD | no |
| Allosteric Prediction | no (-0.630714969) |
| Ortholog in Animals | Dog_ DBI ( ortholog_one2many ) GuineaPig_ DBI ( ortholog_one2one ) Mouse_ Dbi ( ortholog_one2one ) Pig_ DBI ( ortholog_one2one ) Rat_ AABR07036498.1 ( ortholog_one2many ) Rat_ Dbi ( ortholog_one2many ) Rabbit_ DBI ( ortholog_one2one ) |
| Ohnologs | ACBD7 |
| Paralogs | ECI2, ACBD4, ACBD7, ACBD5 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. {ECO:0000269|PubMed:16055366, ECO:0000269|PubMed:21698759}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.047619(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CB8 (X-ray 1.40A ) 2FJ9 (X-ray 1.60A ) |
| DBSNP | rs8192504 rs8192506 rs8192507 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:17953517, ECO:0000269|PubMed:21698759}. Golgi apparatus {ECO:0000269|PubMed:17953517, ECO:0000269|PubMed:21698759}. Note=Golgi localization is dependent on ligand binding (PubMed:17953517). {ECO:0000269|PubMed:17953517}. |
| Mouse PG classification | NA |
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