| Gene Information | |
|---|---|
| Gene Name | DAXX |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000204209 ) 3 ( ENSG00000206206 ) 3 ( ENSG00000206279 ) 3 ( ENSG00000227046 ) 3 ( ENSG00000231617 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UER7 |
| Gene Card | DAXX |
| Uniprot ID | Q9UER7 |
| Pfam | PF03344 |
| In ASD | no |
| Allosteric Prediction | yes (0.701669071) |
| Ortholog in Animals | Alpaca_ DAXX ( ortholog_one2one ) Dog_ DAXX ( ortholog_one2one ) GuineaPig_ DAXX ( ortholog_one2one ) Mouse_ Daxx ( ortholog_one2one ) Pig_ DAXX ( ortholog_one2one ) Rat_ Daxx ( ortholog_one2one ) Rabbit_ DAXX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2KQS (NMR - ) 2KZS (NMR - ) 2KZU (NMR - ) 4H9N (X-ray 1.95A ) 4H9O (X-ray 2.05A ) 4H9P (X-ray 2.20A ) 4H9Q (X-ray 1.95A ) 4H9R (X-ray 2.20A ) 4H9S (X-ray 2.60A ) 4HGA (X-ray 2.80A ) 5GRQ (X-ray 1.58A ) 5KDM (X-ray 3.50A ) 5Y18 (X-ray 2.20A ) 5Y6O (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11495919, ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:9407001}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:9407001}. Nucleus, PML body {ECO:0000269|PubMed:10669754, ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:21482821, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:25275136}. Nucleus, nucleolus {ECO:0000269|PubMed:23222847}. Chromosome, centromere {ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:9645950}. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383). {ECO:0000269|PubMed:11842083, ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:9645950, ECO:0000305|PubMed:10669754}.; [Isoform beta]: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}.; [Isoform gamma]: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}. |
| Mouse PG classification | NA |
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