| Gene Information | |
|---|---|
| Gene Name | DAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q01959 |
| Gene Card | SLC6A3 |
| Uniprot ID | Q01959 |
| Pfam | PF00209 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554). {ECO:0000269|PubMed:17296554, ECO:0000269|PubMed:7637582}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs760871529 rs6345 rs267607068 rs267607069 rs75916702 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11343649, ECO:0000269|PubMed:15505207}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon {ECO:0000269|PubMed:17296554}. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327}. |
| Mouse PG classification | NA |
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