| Gene Information | |
|---|---|
| Gene Name | DARS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 645 |
| Protein Names | Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) |
| Target Name | aspartate--trna ligase, mitochondrial |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000117593 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6PI48 |
| Gene Card | DARS2 |
| Uniprot ID | Q6PI48 |
| Pfam | PF02938; PF00152; PF01336 |
| In ASD | no |
| Allosteric Prediction | no (-0.338722581) |
| Ortholog in Animals | Alpaca_ DARS2 ( ortholog_one2one ) Dog_ DARS2 ( ortholog_one2one ) GuineaPig_ DARS2 ( ortholog_one2one ) Macaque_ DARS2 ( ortholog_one2one ) Mouse_ Dars2 ( ortholog_one2one ) Pig_ DARS2 ( ortholog_one2one ) Rat_ Dars2 ( ortholog_one2one ) Rabbit_ DARS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KARS1, DARS1, NARS1, NARS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AH6 (X-ray 3.70A ) |
| DBSNP | rs4427454 rs121918209 rs121918208 rs121918210 rs1469160736 rs35515638 rs772489337 rs121918207 rs770525873 rs121918212 rs121918213 rs121918205 rs761675657 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:15779907}. |
| Mouse PG classification | NA |
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