| Gene Information | |
|---|---|
| Gene Name | DARS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 501 |
| Protein Names | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000115866 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P14868 |
| Gene Card | DARS1 |
| Uniprot ID | P14868 |
| Pfam | PF00152; PF01336 |
| In ASD | no |
| Allosteric Prediction | yes (0.592546677) |
| Ortholog in Animals | Alpaca_ DARS1 ( ortholog_one2one ) Dog_ DARS1 ( ortholog_one2one ) GuineaPig_ DARS1 ( ortholog_one2one ) Macaque_ DARS1 ( ortholog_one2one ) Mouse_ Dars ( ortholog_one2one ) Pig_ DARS1 ( ortholog_one2one ) Rat_ Dars1 ( ortholog_one2one ) Rabbit_ DARS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DARS2, KARS1, NARS1, NARS2 |
| Tissue | NA |
| Tissue Specificity | Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon. {ECO:0000269|PubMed:23643384}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.049714(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4J15 (X-ray 2.24A ) 5Y6L (X-ray 2.90A ) 6IY6 (X-ray 3.60A ) |
| DBSNP | rs886037635 rs369152939 rs370064817 rs1803165 rs587776985 rs148806569 rs587776984 rs147077598 rs147077598 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}. |
| Mouse PG classification | NA |
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